Lipotoxicity damage of myocardium in obesity

Role of cardiac steatosis and lipotoxicity in obesity cardiomyopathy.

The pandemic of obesity is a devastating health problem and contributes to premature morbidity and mortality. Results from clinical and experimental studies have identified a variety of unfavorable consequences of obesity including cardiovascular diseases, pulmonary diseases, cancer, and sleep disorders. An obesity-triggered parallel increase in the prevalence of type 2 diabetes mellitus is als...

Lipotoxicity of -Cells in Obesity and in Other Causes of Fatty Acid Spillover

A recently identified function of leptin is to protect nonadipose tissues from the nonoxidative metabolic products of long-chain fatty acids (FAs) during periods of overnutrition by increasing the -oxidative metabolism of surplus FAs and reducing lipogenesis. When this protective system fails, harmful products of nonoxidative metabolism such as ceramide increase in nonadipose tissues, including...

[Damage of myocardium in the course of acute xylene poisoning].

Maternal obesity induces fibrosis in fetal myocardium of sheep.

Maternal obesity (MO) has harmful effects on both fetal development and subsequent offspring health. The impact of MO on fetal myocardium development has received little attention. Fibrogenesis is regulated by the transforming growth factor-β (TGF-β)/p38 signaling pathway. Using the well-established model of MO in pregnant sheep, we evaluated the effect of MO on TGF-β/p38 and collagen accumulat...

Reversibility of intrathoracic lipotoxicity in obesity after bariatric surgery: use of magnetic resonance imaging.

Intrathoracic lipotoxicity is the consequence of increased accumulation and biological activity of various fat deposits in obesity, more specifically epicardial (“fat around the heart”) and intramyocardial fat (“fat within the myocardium”). Epicardial fat is located in close proximity to the coronary arteries within the visceral pericardial layer (in contrast to the paracardial or mediastinal f...